罗多莫林A和B的总合成
Weizhao Zhao1, Duo Zhang1, Yuran Wang1
1State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, 222 South Tianshui Road, Lanzhou, Gansu Province 730000, China.
Journal of the American Chemical Society
|November 28, 2023
概括
研究人员首次实现了罗多林A和B的不对称总合成, 这涉及到一个融合的策略,组装关键片段和构建独特的oxa-bicyclo[3.2.1]核心.
科学领域:
- 有机化学
- 自然产品合成
背景情况:
- 罗多莫林A和B是罗多莫兰类型的灰色素.
- 这些天然产品具有独特的d-同质碳骨和oxa-bicyclo[3.2.1]核心.
研究的目的:
- 实现第一个非对称的 rhodomollins A 和 B 的总合成.
- 为构建复杂的灰色结构制定一个融合的策略.
主要方法:
- 融合合成的战略.
- 静态合和-交换用于碎片组装.
- 氧-双循环[3.2.1]核形成的环氧硫酸盐的内分子SN2替代.
- 佩恩/梅恩瓦尔德重组和氧化还原转换用于A环功能化.
主要成果:
- 成功和不对称的 rhodomollins A 和 B 的总合成.
- 在d-homograyanane骨架和oxa-bicyclo[3.2.1]核心的高效构造.
- 在整个合成过程中进行立体选择性控制.
结论:
- 开发的融合策略对于合成复杂的灰色素是有效的.
- 这项工作为进一步的生物研究提供了 rhodomollins A 和 B.
- 合成方法可以应用于其他复杂的天然产品.
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