原交叉连接后的中央有毒皮病:一个案例系列
Pankaj Dongre1, Akhil Bevara2, Rashmi Deshmukh3
1Department of Cataract and Refractive Surgery, L V Prasad Eye Institute, Vishakapatnam, India.
Cornea
|November 28, 2023
概括
中枢毒性角膜病变 (CTK) 发生在1.2%的眼睛,在对角膜的原交叉链接 (CXL) 后. 这个案例系列描述了CTK.
科学领域:
- 眼科医生 眼科 眼科
- 角膜外科手术 角膜外科手术
- 生物材料科学 生物材料科学
背景情况:
- 角膜是一种渐进的角膜脱落.
- 原交叉链接 (CXL) 是逐渐进展的角质的标准治疗方法.
- 中枢毒性角膜病变 (CTK) 是眼科手术后的一种罕见并发症.
研究的目的:
- 在患有角的患者中,报告一个中央毒性角病 (CTK) 病例系列,该病例是在原交叉链接 (CXL) 之后发生的.
- 阐明CXL后CTK的临床特征.
- 为了区分CTK与其他CXL后的角膜不透明度.
主要方法:
- 在2020年1月至2021年9月期间,对964只眼睛进行了CXL治疗,以检测癌.
- 使用的表皮关闭加速CXL协议:20分钟的 рибофлавин浸泡,9mW/cm2 UVA 10分钟.
- 在CXL后分析了临床数据,角膜测量和包膜测量.
主要成果:
- 十二只眼睛 (1.2%) 在CXL后一周内发生CTK.
- CTK呈现为一个精确的局限性,中央形雾.
- 观察到初始的角质测量和心态测量平面化,在12个月内部分恢复;与对照组相比,CTK眼睛的心态测量显著下降.
结论:
- 这项研究描述了原交叉链接 (CXL) 和中央毒性角膜病变 (CTK) 之间的关联.
- 后CXLCTK的临床表现不同于典型的角膜痕或雾.
- CTK是CXL的潜在并发症,需要进一步调查.
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