在艾滋病毒/艾滋病患者中,环境颗粒物和功能下降
Hongfei Ma1, Wei Liang2, Aojing Han2
1Wuhan Center for Disease Control and Prevention.
AIDS (London, England)
|November 28, 2023
概括
暴露于颗粒物 (PM) 在艾滋病毒/艾滋病 (PWHA) 患者中显著损害功能. 这种污染增加了慢性病 (CKD) 的风险,甘油三-葡萄糖 (TyG) 指数起到了调解作用.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
背景情况:
- 颗粒物 (PM) 污染是一个全球性的健康问题.
- 艾滋病毒/艾滋病 (PWHA) 感染者可能更容易受到环境健康风险的影响.
- 慢性病 (CKD) 是PWHA的一个显著的并发症.
研究的目的:
- 调查暴露于各种类型的颗粒物 (PM1,PM2.5,PM10) 和PWHA中的功能之间的关联.
- 为了确定短期和长期的PM暴露对脏健康指标的影响.
- 探索甘油三糖 (TyG) 指数在PM暴露和CKD发病率之间的关系中的潜在调解作用.
主要方法:
- 利用了来自6,958个PWHA的37739次重复测量的数据集.
- 采用线性混合效应模型来评估PM度的移动平均值与估计的膜过率 (eGFR) 和血清肌素 (Scr) 之间的关系.
- 应用了修改后的波桑回归和调解分析,以评估累积颗粒暴露,CKD发病率和TyG指数之间的联系.
主要成果:
- 短期的PM暴露与功能下降有关,由降低的EGFR表示.
- 对PM1,PM2.5和PM10的长期暴露与CKD发病率的增加有显著联系.
- 甘油三糖 (TyG) 指数部分介导了PM暴露与患CKD风险之间的关联.
结论:
- 暴露于颗粒物会对功能产生负面影响,并增加PWHA中CKD风险.
- 甘油三糖 (TyG) 指数在这个人群中,作为将PM暴露与CKD联系起来的途径中的潜在调解者.
- 这些发现强调了减轻空气污染暴露对PWHA脏健康管理的重要性.
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