在社区环境中喘和COVID-19的临床结果
L Jiao1, D Bujnowski1, P Liu1
1Harris County Public Health, 1111 Fannin Street, Houston, TX, 77002, USA.
Public health
|November 28, 2023
概括
与没有喘的人相比,患有喘的人死于COVID-19的风险较低. 这项研究表明,喘可能与COVID-19死亡率相反相关.
科学领域:
- 流行病学 流行病学
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
背景情况:
- 喘和COVID-19死亡率之间的关系尚未得到充分证实.
- 喘是一种常见的慢性呼吸道疾病,影响全球数百万人.
- 了解伴随性疾病对COVID-19结果的影响对于公共卫生至关重要.
研究的目的:
- 研究喘和临床结果之间的关联,特别是COVID-19患者的住院和死亡.
- 将喘患者的COVID-19死亡风险与其他慢性肺病患者的死亡风险进行比较.
主要方法:
- 一项病例控制研究使用了来自德克萨斯州哈里斯县21,765名患者的监测数据.
- 使用后勤回归模型来评估与喘和其他慢性肺部疾病相关的COVID-19严重程度 (住院和死亡) 的几率.
- 对人口统计因素和其他并发症进行调整后的分析,统计显著性设置为P < 0.005.5.
主要成果:
- 在3034名喘患者中,COVID-19病例死亡率为0.75%.
- 患有喘的患者的COVID-19死亡几率较低 (mOR = 0.44,95%CI:0.27-0.69).
- 相反,其他慢性肺病与住院 (mOR = 2.02) 和死亡 (mOR = 1.95) 的几率增加有关.
结论:
- 预先存在的喘似乎与COVID-19死亡率相反相关.
- 喘可能会对COVID-19患者的严重后果或死亡产生保护作用.
- 需要进一步的研究来阐明这种观察到的关联背后的机制.
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