基底节电路中的骨神经元:揭示了新的状状状循环?
Lise Guilhemsang1, Nicolas P Mallet1
1Université de Bordeaux, CNRS, Institut des Maladies Neurodégénératives, F-33000 Bordeaux, France.
Current opinion in neurobiology
|November 28, 2023
概括
一个新发现的GABAergic输入从外部球 (Arkypallidal神经元) 到条纹体提供了对行动选择和抑制的见解. 这些神经元提供显著的反抑制,影响运动控制.
科学领域:
- 神经科学是一个神经科学.
- 基底细胞的电路结构
- 突触传输是突触传输的过程.
背景情况:
- 十年前,从外部球神经元 (GP) 中发现了一种新的GABAergic输入,称为Arkypallidal.
- 这些投射只针对条纹体,是GABA内化的主要来源.
- 它们在条纹信息处理,电路招募和行为影响方面的作用仍在调查中.
研究的目的:
- 为了审查与原型神经元相比,Arkypallidal神经元的解剖功能组织.
- 探索它们独特的分子特性和突触组织.
- 讨论它们对行动选择与抑制的机制性贡献.
主要方法:
- 对Arkypallidal神经元解剖学,功能和分子特征的现有文献的审查.
- 对突触输入/输出组织的分析.
- 讨论关于反抑制机制的最新发现.
主要成果:
- 与原型神经元相比,Arkypallidal神经元表现出不同的解剖功能性质.
- 它们对状体提供了显著的反抑制.
- 这种抑制是由条状投射通路差异调节的.
结论:
- 阿基帕利达神经元在通过反抑制调节条纹活动方面发挥着至关重要的作用.
- 了解它们的功能是解读行动选择和抑制机制的关键.
- 需要进一步的研究,以充分阐明它们对运动控制和行为的贡献.
更多相关视频
10:09Development of a Unilaterally-lesioned 6-OHDA Mouse Model of Parkinson's Disease
Published on: February 14, 2012
51.2K
10:46Acute In Vivo Electrophysiological Recordings of Local Field Potentials and Multi-unit Activity from the Hyperdirect Pathway in Anesthetized Rats
Published on: June 22, 2017
15.7K
相关概念视频
Neural Regulation
39.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.5K
Indirect Motor Pathways
1.5K
The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
1.5K
Neural Circuits
1.3K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
1.3K
Parkinson's Disease: Overview
557
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
557
Direct Motor Pathways
2.0K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
2.0K
Diencephalon: Thalamus and Information Relay
1.6K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
1.6K
