自闭症的抑制功能障碍和社会处理困难:一个全面的叙事审查
Nina-Francesca Parrella1, Aron T Hill2, Lillian M Dipnall3
1Cognitive Neuroscience Unit, School of Psychology, Deakin University, Geelong, Australia.
Journal of psychiatric research
|November 28, 2023
概括
抑制性神经递质胺黄油酸 (GABA) 信号传输的干扰与自闭症和社会处理困难有关. 这篇评论探讨了GABA.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 发展生物学 发展生物学
背景情况:
- 胺黄油酸 (GABA) 是主要的抑制性神经递质,对神经发育和功能至关重要.
- 在GABAergic信号的干扰与神经发育障碍,特别是自闭症谱系障碍 (ASD) 相关.
- 兴奋抑制的不平衡会导致自闭症特征的社会处理缺陷.
研究的目的:
- 审查抑制功能障碍在自闭症中的作用.
- 专注于GABAergic信号与自闭症中社会处理困难之间的联系.
- 探索针对GABA的潜在心理药理干预措施.
主要方法:
- 跨学科研究的全面叙事审查.
- 整合了分子神经生物学,遗传学,表观遗传学和系统神经科学的发现.
- 对神经递质水平 (GABA,谷氨酸) 和它们与自闭症症状的关系的研究分析.
主要成果:
- 自闭症的社会处理困难往往与高谷氨酸和/或降低GABA水平有关.
- 早期发育中的神经化学干扰会影响神经元电路平衡.
- GABA调节显示出作为社会赤字治疗策略的潜力.
结论:
- 抑制功能障碍,特别是涉及GABA,与自闭症的核心社会缺陷有关.
- 了解GABAergic机制提供了对自闭症病理生理学的见解.
- 针对GABA的精神药理学可能为自闭症中社会困难提供新的治疗方法.
关键词:
自闭症 自闭症 自闭症表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.激发性/抑制性的失衡.对于GABA来说,这是一个很好的选择.遗传学 是一个遗传学.谷氨酸酸盐的使用方法社会处理是社会处理.更多相关视频
05:32Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos
Published on: December 7, 2018
9.0K
06:15Using the Visual World Paradigm to Study Sentence Comprehension in Mandarin-Speaking Children with Autism
Published on: October 3, 2018
7.8K
相关概念视频
01:19Autism Spectrum Disorder
100
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
100
01:26Modeling in Therapy
89
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
89
01:28Social Anxiety Disorder
34
Social anxiety disorder, also known as social phobia, is characterized by an intense fear of social situations where one might face humiliation, rejection, embarrassment, or negative evaluation. This disorder leads individuals to avoid activities like casual conversations, public speaking, or seemingly simple tasks such as eating, signing documents, or swimming, in public settings. Its impact extends beyond discomfort, often significantly interfering with daily functioning and quality of life.
34
01:30Negative and Cognitive Symptoms of Schizophrenia
49
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
49
01:04Social Facilitation
32.0K
Not all intergroup interactions lead to negative outcomes. Sometimes, being in a group situation can improve performance. Social facilitation occurs when an individual performs better when an audience is watching than when the individual performs the behavior alone. This typically occurs when people are performing a task for which they are skilled.
32.0K
01:22Personality Disorders: Paranoid and Schizoid
46
Personality disorders represent enduring cognition, affect, and behavior patterns that significantly deviate from societal norms. These maladaptive traits often lead to difficulties in various domains, including interpersonal relationships, occupational settings, and overall psychological well-being. Paranoid personality disorder and schizoid personality disorder are two distinct conditions marked by odd or eccentric behavior.
Paranoid Personality Disorder
Paranoid personality disorder is...
Paranoid Personality Disorder
Paranoid personality disorder is...
46