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针对SARS-CoV-2mRNA接种疫苗的儿童的抗原特异性T细胞反应

Jordan D Philpott¹, Jordan Miller¹, Brittany P Boribong²

¹Mucosal Immunology and Biology Research Center, Massachusetts General Hospital for Children, 114 16(th) Street, Charlestown, MA 02129, USA.

Cell reports. Medicine

|November 28, 2023

概括

SARS-CoV-2 mRNA疫苗在儿童中产生强烈的抗体反应,但T细胞免疫力因年龄而异. 年幼的孩子表现出更多的有效T细胞,可能会影响长期免疫记忆.

科学领域:

免疫学免疫学免疫学
疫苗学疫苗学疫苗学
儿科儿科儿科

背景情况:

在儿童和成年人中,SARS-CoV-2 mRNA疫苗诱导了可比的幽默免疫力.
早期对疫苗接种的T细胞反应尚不清楚,可能与成人模式有所不同.

研究的目的:

研究小儿群体对mRNA疫苗的T细胞反应的性质和动力学.
为了比较不同剂量的mRNA疫苗在儿童中引起的T细胞免疫力.

主要方法:

在青少年 (≥12岁) 接种BNT162b2疫苗后对抗原特异性CD4+T细胞反应的分析.
较年轻儿童 (5-11岁) 与不同剂量的疫苗 (BNT162b2 vs. 100μg mRNA1273) 的T细胞反应的比较.
评估T细胞效应因子表型和与抗受体结合域 (RBD) 抗体水平的相关性.

主要成果:

在青少年 (≥12岁) 中,BNT162b2疫苗接种引发了显著的抗原特异性CD4+T细胞反应.
在5至11岁的队列中,T细胞反应的程度较弱,而较高剂量的mRNA1273并没有改善这种反应.
年龄较小的儿童表现出效应T细胞表型的增加,与较高的抗RBD抗体水平相关,但记忆生成减少.

结论:

儿童对mRNA疫苗的T细胞反应取决于年龄,这表明在生命早期有不同的发育编程.
特定于年龄的适应性免疫力强调了为儿科患者群体优化疫苗原始化条件的必要性,包括剂量和潜在辅助剂.

关键词:

对于T细胞免疫的免疫力.早期生命免疫力免疫力这是mRNA疫苗.儿科COVID-19 儿童 COVID-19 儿童

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