在2型糖尿病患者中,脂质格局的循环组织受到干扰
Flore Sinturel1, Simona Chera2, Marie-Claude Brulhart-Meynet3
1Division of Thoracic and Endocrine Surgery, Department of Surgery, University Hospitals of Geneva, 1211 Geneva, Switzerland; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland; Institute of Genetics and Genomics in Geneva (iGE3), 1211 Geneva, Switzerland.
2型糖尿病会破坏人体脂肪和血液中的每日脂质模式. 脂质代谢中的这些时间变化为开发基于时间的生物标志物提供了新的途径.
科学领域:
- 代谢学 代谢学 代谢学
- 时间生物学 时间生物学
- 内分泌学 在内分泌学.
背景情况:
- 脂质平衡在人体组织中表现出白天模式,如肌肉和胰腺小岛.
- 代谢失调,如2型糖尿病,可以改变这些自然的日常节奏.
研究的目的:
- 为了研究皮下白色脂肪组织 (SAT) 和血清中脂质代谢的日常调节.
- 为了比较非糖尿病 (ND) 和2型糖尿病 (T2D) 个体之间的脂质代谢物节律性.
主要方法:
- 运用并列和液态染色学质谱仪进行脂质组学分析.
- 分析了ND和T2D人类志愿者 (n=12) 的样本,并在独立队列 (n=32) 中验证了结果.
主要成果:
- 在约440个已识别的脂质代谢物中,大约8%的血清和SAT都表现出白天节律性.
- 在ND和T2D受试者之间,特定的节律性脂质有所不同,在清晨发现了显著的变化.
- 在T2D患者的血清和SAT中发现的节律性脂质显示出明显的相位差异.
结论:
- 2型糖尿病会导致人类脂质平衡的显著时间和组织特异性变化.
- 这些发现为开发T2D的时间依赖性脂质生物标志物提供了关键的见解.
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