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Updated: Jul 9, 2025

Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes
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通过祖先序列重建识别的增强凝血因子IX变体的人性化和功能性特征

Christopher W Coyle1, Kristopher A Knight1, Harrison C Brown2

  • 1Molecular and Systems Pharmacology Graduate Program, Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University School of Medicine, Atlanta, Georgia, USA.

Journal of thrombosis and haemostasis : JTH
|November 28, 2023
PubMed
概括

研究人员复活了古老的凝血因子IX (FIX) 变体,发现了具有增强活性的An96. 他们确定了一个强大的FIX基因治疗候选人的关键替代品 (ET9) 血友病B.

关键词:
腺相关病毒的病毒.第九因子XIX因子基因治疗的基因疗法血友病 B 型 血友病 B 型蛋白质工程工程 蛋白质工程

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