新生儿出血评分系统:系统性审查
Rozeta Sokou1, Stavroula Parastatidou2, Aikaterini Konstantinidi1
1Neonatal Intensive Care Unit, "Agios Panteleimon" General Hospital of Nikea, Piraeus, Greece.
Seminars in thrombosis and hemostasis
|November 28, 2023
概括
目前的新生儿出血预测模型需要改进. 开发强大的模型需要更好的标准,并纳入个性化输血治疗的临床因素.
科学领域:
- 新生儿医学 新生儿医学
- 临床流行病学临床流行病学
- 生物统计学 生物统计学
背景情况:
- 新生儿,特别是早产婴儿的出血是一个显著的风险.
- 现有的新生儿出血预测模型在概括性方面存在局限性.
- 腹腔内出血 (IVH) 是早产新生儿的常见和严重并发症.
研究的目的:
- 系统地审查和评估当前新生儿出血预测模型.
- 评估这些模型的普遍应用潜力.
- 确定在新生儿出血风险预测方面需要改进的领域.
主要方法:
- 在2023年9月20日之前对PubMed和Scopus数据库进行系统审查.
- 包括关于开发和/或验证新生儿出血风险预测模型的研究.
- 分析了19项研究,确定了18种不同的预测模型.
主要成果:
- 在18个确定的模型中,只有6个经过了任何形式的验证 (内部,时间或外部).
- 大多数模型仅依赖于临床变量,忽视了关键的静血样本和临床过程.
- 只有一个研究为模型开发提供了样本大小的理由.
结论:
- 目前的新生儿出血预测模型是不理想的,需要增强的发展标准.
- 未来的模型必须将临床变量与静血样息进行整合,以进行准确的风险评估.
- 大规模的协作队列研究对于开发可靠的模型来指导个性化输血治疗至关重要.
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