胃肠道外科手术中的亲肠道菌素:系统性审查
Siv Fonnes1, Masja Klindt Fonnes1, Barbara Juliane Holzknecht2,3
1Centre for Perioperative Optimisation, Department of Surgery, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
Drug research
|November 28, 2023
概括
在胃肠道手术前或手术期间给出的外科手术期间的门菌素与手术后感染并发症的低率和少数轻微伤害有关. 这种抗生素预防在手术环境中显示出前途.
科学领域:
- 传染性疾病 传染性疾病
- 手术感染 手术感染
- 药理学 药理学是指药理学的学科.
背景情况:
- 手术后的传染性并发症是胃肠道外科手术的一个重要问题.
- 研究有效的预防策略对于改善患者的治疗结果至关重要.
- 斯福米是一种具有广谱活性的抗生素.
研究的目的:
- 为了评估围手术期间的亲肠道福斯福米在预防胃肠道手术后的传染性并发症的疗效.
- 在这种情况下,要描述福米的使用方案和安全性.
主要方法:
- 对涉及胃肠道外科手术和周围手术期间通过肠道给药菌素的原始研究进行系统审查.
- 搜索了三个数据库; 在提取数据之前注册了协议.
- 使用柯克兰手册或纽卡斯尔-太华尺度评估偏差风险;执行叙述综合.
主要成果:
- 包括15项研究,其中包括1,029名接受围手术时福米治疗的患者.
- 感染并发症的发生率很低:手术部位感染率为0-1% (紧急) 和0-10% (可选).
- 危害是罕见的,轻微的,主要是胃肠道.
结论:
- 经外科手术期间的亲肠道菌素,通常与甲尼达结合,在减少胃肠道手术后的感染性并发症方面表现出有效性.
- 斯福米辛表现出良好的安全性,并具有最小和轻微的不良反应.
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