增强的外部反推力增加了冠状动脉微血管疾病冠状动脉流量储备
Qian Wang1, Jia Hao1, Wenjun Jiang1
1From the Department of Cardiology, The first hospital of Qinhuangdao, Hebei Medical University, Qinhuangdao, Hebei, China.
Saudi medical journal
|November 28, 2023
概括
增强的外部反推力 (EECP) 改善了冠状动脉流量储备 (CFR) 和冠状动脉微血管疾病 (CMD) 患者的生活质量. EECP治疗显著提高了CFR和患者报告的结果.
科学领域:
- 心脏病学 心脏病学
- 血管医学 血管医学
- 非侵入性心脏病学 非侵入性心脏病学
背景情况:
- 冠状动脉微血管疾病 (CMD) 在心血管医学中是一个重大挑战.
- 对于CMD患者来说,有效的治疗选择有限,影响他们的生活质量.
- 了解CMD的新治疗方法对于改善患者的治疗结果至关重要.
研究的目的:
- 评估在被诊断为冠状动脉微血管疾病 (CMD) 的患者中增强外部对冲动 (EECP) 的疗效.
- 评估EECP对冠状动脉流量储备 (CFR),内皮功能标志物和CMD患者的生活质量 (QoL) 的影响.
主要方法:
- 一项随机对照试验,涉及83名冠状动脉微血管疾病患者,分为EECP (n=41) 和对照 (n=42) 组.
- 冠状动脉流量储备 (CFR) 是通过 transthoracic 多普勒心声扫描在4周的干预期之前和之后测量.
- 使用ELISA量化了内皮氧化合成酶 (eNOS) 和内皮素-1 (ET-1) 的血清水平,并通过西雅图心风问卷 (SAQ) 和加拿大心血管学会 (CCS) 心风等级评估生活质量.
主要成果:
- 经过四周,与对照组相比,EECP组的CFR显著改善 (p<0.05).
- 在EECP队列中,EECP疗法导致内甲蛋白-1的显著降低和eNOS的显著上调.
- 接受EECP治疗的患者在西雅图Angina问卷中获得了更高的分数,加拿大心血管学会Angina类减少.
结论:
- 增强外部反推力 (EECP) 是一种有前途的非侵入性疗法,用于改善冠状动脉微血管疾病 (CMD) 患者的冠状动脉流量储备.
- EECP治疗对内皮功能标志物产生积极影响,特别是增加eNOS和降低ET-1.
- EECP显著提高了患有冠状动脉微血管疾病的患者的生活质量,减少了心肌痛症状.
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