常见呼吸道感染对心血管风险的估计因果影响:元分析
Hannah M la Roi-Teeuw1, Maarten van Smeden2,3, Maureen Bos4
1Department of General Practice and Nursing Science, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands h.m.teeuw@umcutrecht.nl.
Open heart
|November 28, 2023
概括
呼吸道感染 (RTIs) 显著增加心血管疾病的风险,特别是在感染后的一个月内. 管理RTIs可能对心血管风险管理至关重要,特别是在脆弱人群中.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 在常见的呼吸道感染 (RTIs) 和心血管疾病 (CVD) 风险之间存在确定的关联.
- 在心血管风险管理中RTIs的作用尚不清楚.
- 这项研究调查了RTIs和心血管疾病发生之间的因果关系.
研究的目的:
- 系统地审查和元分析RTIs对心血管疾病发病率的因果关系.
- 为了量化一般人群中常见的RTIs后的CVD风险.
主要方法:
- 在2022年11月4日之前,对MEDLINE和EMBASE数据库进行系统搜索.
- 包括评估RTI暴露后心血管结果的病因研究.
- 使用随机效应模型的元分析,具有偏差风险和ROBINS-E和GRADE评估的证据确定性.
主要成果:
- 包括34项涉及超过6500万个人的研究;大多数有偏见的高风险.
- COVID-19显著增加了30天至一年内心肌梗塞,中风,肺栓塞和深静脉血栓形成的风险.
- 其他RTIs也会增加30天内心肌梗塞和中风的风险,在更长的随访期内影响会减少.
结论:
- 在感染后的一个月内,RTIs显著增加心血管疾病的风险,增加1.5到5倍.
- RTIs代表了心血管风险管理策略的临床相关目标.
- 对于RTIs和心血管健康的综合管理,应特别注意高风险人群.
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