番茄和提取物通过增加老年小鼠的大脑衍生神经营养因子水平来协同改善认知功能
Kyeong-No Yoon1,2,3, Yidan Cui2,3,4, Qing-Ling Quan2,3,4
1Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Republic of Korea.
The British journal of nutrition
|November 28, 2023
概括
番茄和提取物协同增强老年小鼠的认知功能和神经发生. 这种组合通过提高突触可塑性和激活关键分子通路来支持大脑健康.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 营养科学 营养科学
背景情况:
- 大脑衰老与由于神经病理学积累而导致的认知衰退有关.
- 番茄和中的营养素可能会支持认知功能和大脑健康.
- 之前的研究表明,西红和对氧化应激和衰老有保护作用.
研究的目的:
- 研究番茄和乙醇提取物 (TEE和LEE) 对老年小鼠认知功能和神经生成的影响.
- 探索结合TEE和LEE的潜在协同效应.
- 阐明任何观察到的协同效应背后的分子机制.
主要方法:
- 年龄大小的小鼠 (12个月大) 被口服TEE,LEE或两者的混合物,持续9周.
- 用新型物体识别测试来评估认知功能.
- 神经生成通过双皮质素免疫组织化学染色来评估.
- 分析了分子变化,包括受体和蛋白质水平以及酸化.
主要成果:
- 单个TEE或LEE的使用显示了认知功能和神经发生的中度改善.
- TEE + LEE混合物证明了认知功能和神经发生的显著协同增强.
- 观察到N-甲基-d-酸盐受体2B,突触后密度蛋白95和来自大脑的神经营养因子 (BDNF) 水平的协同增加.
- BDNF/热氨酸受体激酶B (TrkB) /细胞外信号调节激酶 (ERK) 路径酸化也在协同上升.
结论:
- 番茄和乙醇提取物的组合协同改善了老年小鼠的认知功能和神经发生.
- 这种协同效应通过来自大脑的神经营养因子 (BDNF) /热胺受体激酶B (TrkB) /细胞外信号调节激酶 (ERK) 信号通路进行调节.
- TEE + LEE混合物代表了一种有前途的营养策略,可以在衰老期间保持认知健康.
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