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Updated: Jul 9, 2025

Study of Protein-protein Interactions in Autophagy Research
14:08

Study of Protein-protein Interactions in Autophagy Research

Published on: September 9, 2017

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通过Rab7的无处不在,TRAF6触发了受Mycobacterium感染的宿主自

Qinmei Ma1,2, Jialin Yu1,2, Li Liu1,2

  • 1School of Life Science, Ningxia University, Yinchuan, NingXia, 750021, China.

Cell death discovery
|November 28, 2023
PubMed
概括

瘤亡因子受体相关因子6 (TRAF6) 通过促进溶酶体融合来调节Mycobacterium诱导的自. 缺少TRAF6会使肺部损伤恶化,并有助于细菌的生存.

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Rab Cascades

Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
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Rab proteins constitute the largest family of monomeric GTPases, of which 70 members are present in humans. Rab proteins and their effectors regulate consecutive stages of vesicle transport such as vesicle transport, docking, and fusion to the correct recipient membrane.
Rab proteins switch between a cytosolic, GDP-bound inactive state and a membrane-anchored, GTP-bound active state. By themselves, Rabs show slow rates of GDP/GTP exchange and GTP hydrolysis. Thus, Rab proteins are considered...
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