重复的被动视觉体验调节自发和不熟悉的刺激引起的神经活动
Suraj Niraula1, William L Hauser1, Adam G Rouse2
1Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS, 66045, USA.
Scientific reports
|November 28, 2023
概括
重复的视觉体验会改变小鼠视觉皮层中的神经活动. 熟悉性减少了对熟悉刺激的选择性,同时增强了对新鲜刺激的反应,表明了经验的内部模型.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 感官处理 感官处理
背景情况:
- 熟悉重复的刺激会减少神经和行为反应.
- 增强的新奇性检测是与熟悉性相关的关键功能.
- 熟悉性和新奇性检测的神经基础和细胞机制尚未完全理解.
研究的目的:
- 研究重复的被动视觉体验如何改变小鼠视觉皮层中的神经活动.
- 识别熟悉的神经相关物和增强新奇性检测的机制.
- 检查对熟悉和不熟悉的刺激的反应中自发和唤起的神经活动的变化.
主要方法:
- 用小鼠视觉皮质作为模型系统.
- 在多天内多次呈现45°定位格子刺激.
- 记录和分析神经活动对熟悉 (45°),不熟悉 (90°,135°) 和自然图像刺激的反应.
主要成果:
- 熟悉引起了刺激竞争,减少了45度刺激的选择性,但增加了90度刺激的选择性.
- 与熟悉的刺激相隔45°的方向调整的神经元显示出主导的局部功能连接.
- 对自然图像的反应在表现出刺激竞争的神经元中微妙地增加,自发活动类似于熟悉的刺激唤起的活动.
结论:
- 重复的被动体验会改变视觉皮层中的神经选择性和功能连接性.
- 这些变化表明形成了一个内部模型,代表了改变的感觉体验.
- 这些发现提供了关于熟悉,新奇感知和感官适应的基础神经机制的见解.
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