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将非洲祖先的基础结构与前列腺癌健康差异联系起来
Kazzem Gheybi1, Naledi Mmekwa2, Maphuti Tebogo Lebelo3
1Ancestry and Health Genomics Laboratory, Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, 2006, Australia.
Scientific reports
|November 28, 2023
概括
撒哈拉以南非洲的前列腺癌 (PCa) 风险与贫困和特定的生活方式因素有关. 在非洲,祖先的多样性,特别是在加人中,有助于PCa健康差异.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 遗传学 遗传学 是一个
背景情况:
- 前列腺癌 (PCa) 在撒哈拉以南非洲是一个重大的健康挑战,死亡率通常与非洲血统有关.
- 在非洲大陆内对PCa风险因素的研究有限,忽视了关键的祖先多样性.
研究的目的:
- 调查南非多民族人口中前列腺癌的流行病学,人口统计和生活方式风险因素.
- 探索非洲祖先多样性在前列腺癌差异中的作用.
主要方法:
- 分析了南非前列腺癌研究 (SAPCS) 中1387名男性的数据.
- 检查风险因素 (贫困,性病,勃起功能障碍,发) 与PCa诊断,等级和诊断时的年龄之间的关联.
- 调查PCa风险跨越不同族群和祖先的基层结构.
主要成果:
- 贫困显著影响了PCa等级和诊断时的年龄.
- 性传播疾病,勃起功能障碍,妇产和发模式与PCa风险有关.
- 黑人种族与增加PCa诊断和侵略性疾病相关,与非洲裔美国人的数据保持一致.
- 非洲祖先人口的基层结构显示出差异:Tsonga人患高级PCa的风险更高,而南非有色人种患侵袭性疾病的风险更低.
- 在黑人族群中发现PCa诊断 (OR=1.44) 和侵略性疾病 (ISUP ≥4:OR=2.25) 的显著关联.
- 松冈人群的疾病发病风险增加 (ISUP ≥4:OR=3.43).
- 南非有色人种的侵袭性疾病风险降低 (ISUP ≥3:OR=0.38).
结论:
- 贫困和特定的生活方式因素是南非前列腺癌风险和严重性的关键因素.
- 在非洲的祖先多样性,包括人口基层结构,显著影响前列腺癌的健康差异.
- 在研究中纳入非洲祖先的多样性对于理解和解决PCa健康不平等至关重要.
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