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慢性血栓栓塞性肺高血压的特定个体的一维流体动力学模型

Amirreza Kachabi¹, Mitchel J Colebank¹, Naomi C Chesler²

¹Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center, Department of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA.

Biomechanics and modeling in mechanobiology

|November 28, 2023

概括

慢性血栓栓塞性肺高血压 (CTEPH) 增加了肺动脉的硬度,并改变了血液流动的动态. 这项研究使用计算建模将这些变化与疾病严重程度联系起来,为有针对性的患者干预提供了潜力.

科学领域:

心血管研究研究心血管研究
生物医学工程生物医学工程
肺部医学肺部医学

背景情况:

慢性血栓塞性肺高血压 (CTEPH) 是由肺动脉阻塞引起的,但潜在的机械生物学驱动因素尚不清楚.
测量受CTEPH影响的小肺动脉中的血液动力学变化是具有挑战性的.

研究的目的:

通过特定学科的计算流体动力学 (CFD) 方法,研究CTEPH对肺动脉力学和血液动力学的影响.
为了确定CTEPH进展和严重程度的新生理标志物.

主要方法:

在CTEPH的大型动物模型上应用了特定于主题的1D CFD模型.
分析了肺动脉壁硬度,时间平均壁剪应力 (TAWSS) 和振荡剪指数 (OSI) 的变化.
量化了使用新型参数的血栓发生率,并将其与平均肺动脉压力 (mPAP) 相对应.

主要成果:

CTEPH显著增加了肺动脉壁的硬度,并在大动脉和小动脉中减少了TAWSS.
在CTEPH中,更高的百分比的内巴动脉网络表现出低TAWSS和高OSI.
增加的mPAP与升高的mPAP有很强的相关性,这表明它驱动疾病的严重程度.

结论:

专用CFD框架有效预测CTEPH相关的血液动力学和机械变化.
新的参数显示了作为CTEPH进展的生理标志物的潜力.
这种方法可以指导针对单个CTEPH患者开发有针对性的干预措施.

关键词:

1D CFD 在线交易在CTEPH的基础上,血液动力学建模模型墙壁剪切应力压力是什么

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