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Updated: Jul 9, 2025

Targeting Cysteine Thiols for in Vitro Site-specific Glycosylation of Recombinant Proteins
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甲基醇诱导的修改以稳定治疗性蛋白质:一篇评论

Nainika Prashant Kotian1, Anusha Prabhu1, Tenzin Tender1

  • 1Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576104, India.

The protein journal
|November 28, 2023
PubMed
概括

甲基醇 (MGO) 通过形成交叉链接,影响治疗性蛋白质的稳定性和伴侣活性. 了解MGO的理解

关键词:
陪伴者是指一个陪伴者.甲基格里奥克萨尔 (Methylglyoxal) 是一种治疗蛋白质的治疗药物α-Crystallinallin 的使用情况.

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Protein Glycosylation

Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
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