高风险患者的COVID-19早期组合疗法
Hans Martin Orth1,2, Charlotte Flasshove1,2, Moritz Berger3
1Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf, (ABCD), Aachen, Germany.
Infection
|November 28, 2023
概括
早期的COVID-19联合治疗显著减少了高风险患者的长期病毒分泌,包括患有血液性恶性瘤的患者. 这种方法表明病毒清除速度快,毒性低.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 长期严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 泄漏是免疫功能低下个体的一个问题.
- 对于COVID-19的标准单疗法可能无法可靠地预防长时间的病毒分泌.
- 双重抗病毒疗法正在研究协同效应.
研究的目的:
- 为了比较使用抗病毒药物和单克隆抗体 (mAB) 组合的COVID-19治疗策略.
- 为了评估双重疗法的有效性,防止长时间的SARS-CoV-2病毒泄漏.
- 为了确定与长时间病毒分泌相关的风险因素.
主要方法:
- 这是一项回顾性多中心研究,在Omicron手术期间涉及144名患者.
- 尼尔马特里尔维尔/里托纳维尔,雷德西维尔,莫尔努皮拉维尔和/或mABs的组合相比较.
- 使用回归和生存分析评估了长时间的病毒分泌 (≥10^6副本/毫升在第21天) 和高病毒载荷的持续时间.
主要成果:
- 14.6%的患者经历了长时间的病毒分泌,特别是那些患有血液性恶性瘤的人 (OR 3.5).
- 诊断后5天后开始的治疗与更长的脱落有显著的关联 (p<0.01).
- 组合治疗显示了轻度至中度的COVID-19疗程,副作用很少.
结论:
- 在85.6%的病例中,早期的COVID-19联合治疗有效地预防了长时间的病毒泄漏.
- 个性化双重治疗方法可能有利于高风险患者,因为病毒清除速度快,毒性低.
- 血液性恶性瘤是长期散布SARS-CoV-2的重要危险因素.
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