在常见的可变免疫缺陷疾病患者中,内镜和组织病理学暗示感染,具有胃肠道症状
1Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
BMC gastroenterology
|November 29, 2023
概括
常见的可变免疫缺陷障碍 (CVID) 患者经常出现胃肠道问题. 结节性淋巴细胞增生症等内镜检测结果可能表明CVID患者的感染,有助于诊断和治疗.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 内部医学 内部医学
背景情况:
- 在常见可变免疫缺陷障碍 (CVID) 中,胃肠道 (GI) 的参与尚不清楚.
- 冠状病毒感染患者经常出现胃肠道症状和感染.
研究的目的:
- 评估患有胃肠道症状的CVID患者的临床,内镜和组织病理特征.
- 确定CVID中胃肠道症状,内镜检查结果和感染之间的相关性.
主要方法:
- 对21名具有胃肠道症状的CVID患者进行了回顾性研究.
- 从2000年到2020年对临床,传染病,内镜和组织病理学数据的分析.
主要成果:
- 慢性腹 (95.2%),低体重和吸收不良 (>85%) 是普遍存在的.
- 小肠状缩 (90.5%) 和缺乏血细胞 (95%) 是常见的组织病理学发现.
- 结节性淋巴细胞增生 (NLH) 在内镜上与较高的感染率 (85.7%) 相关联,主要是Giardia和细菌.
结论:
- 冠状病毒常常影响肠道,特别是小肠.
- 内镜NLH可以表明CVID患者的胃肠道感染.
- 综合性评估有助于CVID诊断,同时感染的识别和治疗.
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