抗性指数与病进展和死亡率的关联
Chloe Kharsa1, Chadia Beaini1, Dania Chelala2
1Faculty of Medicine, Saint Joseph University of Beirut, Beirut, Lebanon.
BMC nephrology
|November 29, 2023
概括
较高的抗性指数 (RRI) 预测慢性病 (CKD) 患者的死亡风险更高,即使在改变生活方式后也是如此. RRI作为CKD进展和不良结果的独立预后因素.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 医疗成像医学成像
- 心血管研究研究心血管研究
背景情况:
- 抗性指数 (RRI) 是病进展的公认预测指标.
- 关于死亡率和透析开始的RRI的预后价值需要进一步评估,特别是在考虑干预后.
研究的目的:
- 评估慢性病 (CKD) 患者的RRI和死亡率之间的关联.
- 评估RRI和透析开始之间的联系.
- 为了确定RRI是否是一个独立的预后因素,在调整治疗和生活方式的修改后.
主要方法:
- 对CKD患者的回顾性分析至少进行了两年 (2006-2019) 的跟踪.
- 卡普兰-梅尔和日志等级测试用于正常和高RRI组之间的生存比较.
- 考克斯回归分析,以评估RRI与结果之间的关联,经过调整以考虑混因素.
主要成果:
- 分析了192名患者,124名患者的RRI≥0.7.7.
- 较高的RRI与基线eGFR负相关 (斯皮尔曼的 ρ = -0.521,p < 0.001).
- 患有RRI<0.7的患者的生存率显著改善 (Log Rank测试<0.001).
- 升高的RRI与增加的死亡率相关 (调整HR=1.04,p=0.036) 和透析开始 (HR=1.06,p=0.011).
结论:
- 升高的RRI (≥0.7) 与CKD患者死亡风险更高有关.
- RRI显示出作为CKD的独立预后因素的潜力.
- 这些发现强调了RRI在CKD患者风险分层中的重要性.
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