在英国对产前C型肝炎病毒检测的快速审查
M P Hibbert1,2, R Simmons3,4, S Mandal3,4
1Sexually Transmitted Infections and HIV Division, Blood Safety, Health Security Agency (UKHSA), Hepatitis, London, England, UK. matthew.hibbert@ukhsa.gov.uk.
BMC pregnancy and childbirth
|November 29, 2023
概括
在英国,针对型肝炎病毒 (HCV) 的产前查显示,抗体检测阳性率为0.38%,RNA检测阳性率为0.22%. 这凸显了产前检测在发现新病例和实现消除目标方面的潜力.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
- 病毒学 病毒学
背景情况:
- 英国的目标是消除病毒性肝炎,与世卫组织的目标保持一致.
- 像产前检测这样的新策略对于实现这些消除目标至关重要.
- 了解孕妇群体中C型肝炎病毒 (HCV) 患病率是关键.
研究的目的:
- 在英国产前环境中审查型肝炎特异性抗体 (抗HCV) 和HCVRNA测试阳性.
- 为 HCV 的产前检测策略提供指导.
- 评估产前查在HCV病例发现中的作用.
主要方法:
- 快速审查2000年1月至2022年6月期间发表的研究.
- 在PubMed和Web of Science进行的关于在产前环境中进行抗HCV测试的搜索.
- 包括10项研究结果的叙述综合.
主要成果:
- 抗HCV测试阳性程度在0.1%至0.99%之间 (中位数为0.38%).
- HCVRNA阳性范围在0.1%至0.57%之间 (中位数为0.22%).
- 一项研究表明,成本效益为每年9,139英.
结论:
- 产前检测是识别新的C型肝炎病例的重要工具.
- 全民选择退出HCV产前检测的贡献需要重新考虑.
- 实施产前查可以显著帮助实现病毒性肝炎消除目标.
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