三糖-葡萄糖指数,功能和心血管疾病:一项国家队列研究
Cancan Cui1, Lin Liu1, Te Zhang1
1China-Japan Union Hospital of Jilin University, Jilin University, Changchun, China.
Cardiovascular diabetology
|November 29, 2023
概括
甘油三糖 (TyG) 指数和功能受损显著增加心血管疾病的风险. 功能部分调解了TyG指数和心血管事件之间的联系.
科学领域:
- 心血管医学 心血管医学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 甘油三糖 (TyG) 指数是心血管疾病 (CVD) 风险的新兴标志物.
- 功能在TyG指数和心血管疾病之间的关联中的作用仍然不清楚.
研究的目的:
- 调查TyG指数和功能与心血管疾病的联合关联.
- 评估功能在TyG指数-心血管疾病关系中的调解作用.
主要方法:
- 使用中国健康与退休长度研究 (CHARLS) 数据的队列研究.
- 参与者在基线时没有心血管疾病.
- 三糖-葡萄糖 (TyG) 指数计算为Ln [禁食三糖 (mg/dL) ×禁食葡萄糖 (mg/dL) /2].
- 通过估计的膜过率 (eGFR) 评估功能.
- 进行了考克斯回归和调解分析.
主要成果:
- 总共分析了6,496名参与者.
- 较高的TyG指数和较低的eGFR独立地与心血管疾病风险增加有关.
- 高TyG指数和低eGFR的组合显示出最高的心血管疾病风险 (HR, 1.870).
- 降低的eGFR显著介导了TyG指数和心血管疾病之间的关联的29.6%.
结论:
- 提升的TyG指数和功能受损协同增加心血管疾病的风险.
- 功能在TyG指数和心血管风险之间的关系中发挥着重要的调解作用.
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