皮肤上的Inonotus obliquus sclerotia不同于内部组织的化合物组成,抗氧化活性和相关的真菌
Yijia Zhang1, Qiao Liu1, Yong Sun1
1Key Laboratory of Biotechnology for Medicinal Plants of Jiangsu Province, School of Life Sciences, Jiangsu Normal University, Xuzhou 221116, China.
FEMS microbiology letters
|November 29, 2023
概括
这项对Inonotus obliquus的研究发现,其表皮和内部组织在生物活性化合物上有所不同. 分离这些部分可以优化这种有价值的真菌的药用.
科学领域:
- 药用菌类学 药用菌类学
- 植物化学 植物化学
- 自然产品化学 自然产品化学
背景情况:
- (Inonotus obliquus) 是一种具有多种健康应用的药用真菌.
- 优化I. obliquus的利用需要对其特定组织的生物活性成分有详细的了解.
- 以前的研究还没有完全阐明I. obliquus sclerotia的表皮和内部组织之间的差异.
研究的目的:
- 分析和比较I. obliquus sclerotia的表皮和内部组织中的多,多糖,黄和总三烯的含量.
- 评价来自硬化菌不同部位的提取物中抗氧化能力和DPPH自由基清除能力.
- 识别和比较表皮和内部组织中存在的相关真菌.
主要方法:
- 从五种I. obliquus sclerotia的表皮和内部组织中分析生物活性化合物 (多,多糖,黄,三烯).
- 组织提取物的总抗氧化能力和DPPH激素清除活性的评估.
- 从表皮和内部组织中分离和识别相关真菌.
主要成果:
- 外皮组织显示出较高的多醇含量,但与内部组织相比,黄类和总三类含量较低.
- 聚糖含量各不相同,一些样本在表皮中显示出更高的水平.
- 内部组织提取物表现出优越的DPPH激素清除能力,内部组织的抗氧化能力相当或更高.
结论:
- 在I. obliquus的表皮和内部组织之间,生物活性化合物的分布存在显著差异.
- 内部组织表现出更强的抗氧化剂和自由基清除活动.
- 建议将表皮和内部组织分离,以优化I. obliquus的药用应用.
相关概念视频
02:22Introduction to Plant Diversity
From Water to Land
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:29Overview of Fungi
Fungi are a diverse group of eukaryotes more closely related to animals than other eukaryotes. Fungal cell walls comprise chitin, a polysaccharide that provides structural strength, and glucans, which contribute to flexibility and integrity. Other polysaccharides, such as mannans and galactosans, may supplement or replace chitin in some fungi. These adaptations, along with their preference for acidic environments and tolerance for high osmotic pressure, enable fungi to thrive in various...
01:29Fungal Group Zygomycota
Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
01:26Fungal Phylum Basidiomycota
Basidiomycota is a diverse phylum of fungi that includes ecologically significant decomposers such as white rot fungi, symbionts like mycorrhizal fungi, plant pathogens such as rusts and smuts, and edible species like Agaricus bisporus (the common button mushroom). These fungi play crucial roles in nutrient cycling, symbiotic relationships, and even human health. Their defining feature is the basidium, a microscopic club-shaped structure responsible for producing basidiospores.Fruiting Bodies...
01:15Antifungal Agents
Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...