肠道感受:抑郁,焦虑,精神药物和肠道微生物组之间的关系
S Brushett1,2, R Gacesa1,3, A Vich Vila4,5
1Department of Genetics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.
Gut microbes
|November 29, 2023
概括
肠道微生物组与抑郁症和焦虑症等内化疾病有关. 这些肠道细菌的差异与疾病本身有关,而不是主要与精神药物使用有关.
科学领域:
- 微生物学与神经科学 微生物学与神经科学
- 肠-大脑轴研究研究
- 精神疾病和微生物组
背景情况:
- 肠道微生物组在肠-大脑轴中发挥着作用.
- 之前关于这种关系的研究受到小样本大小和缺乏对心理药物使用 (PTD) 的调整的限制.
- 内化障碍,如抑郁和焦虑,是普遍存在的,影响生活质量.
研究的目的:
- 研究肠道微生物组与内化疾病之间的关系.
- 为了调整PTD和其他药物的混效应.
- 为了探索特定的细菌物种和所涉及的代谢途径.
主要方法:
- 对来自"生命线"队列的7656名参与者的肠道微生物组组成进行了分析.
- 对照组和患有内化障碍的个体之间的比较 (抑郁症,主要抑郁症,泛性焦虑症等). ) 的情况.
- 对PTD,其他药物,功能性胃肠疾病和易怒肠综合征的统计调整.
主要成果:
- 17种与抑郁症和3种与焦虑症相关的细菌物种.
- 经过对PTD进行调整后,大约90%的这些关联仍然是显著的.
- 对于生产丁酸盐的细菌 (例如, *Ruminococcus bromii*) 和 *Bifidobacterium bifidum *,以及托,谷氨酸和多巴胺代谢途径发现了负面关联.
结论:
- 内化障碍,而不是PTD使用,与肠道微生物群差异显著相关.
- 肠道中的特定细菌物种和代谢途径与抑郁和焦虑有关.
- 这些发现突出了肠道微生物组在内化疾病的病理生理学中的作用.
关键词:
抑郁症 (Dysthymia) 是一种精神疾病.一般性焦虑障碍是一般性焦虑障碍.我们的肠道微生物组.肠-大脑轴 肠-大脑轴内部化障碍是一种内在化障碍.大型抑郁症主要是抑郁症.精神药物 精神药物是一种精神药物.更多相关视频
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