PERPRISE:对PERampanel作为PRImary或SEsecondarily泛起的强力克隆性发作患者的唯一辅助治疗的前性非干预性研究:第一个中间分析
Bernhard J Steinhoff1,2, Tobias Goldmann3, Edgar Kockelmann3
1Kork Epilepsy Center, Kehl-Kork, Germany.
在PERPRISE研究中,perampanel作为治疗的补充抗发作药物 (ASM) 有效. 在6个月后,78%的患者继续治疗,59%的患者实现了无发作,83%的患者发作频率降低.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 治疗通常需要多种抗发作药物 (ASM).
- 佩拉曼奈尔是一种用于焦点和泛发作的ASM.
- 在真实世界中,关于香的疗效和耐受性的数据是有价值的.
研究的目的:
- 评估PERPRISE研究 (NCT04202159) 的中间结果.
- 评估佩拉曼奈尔作为唯一辅助的ASM在成年人的焦点到双边强力克隆发作 (FBTCS) 或初级泛性强力克隆发作 (GTCS).
主要方法:
- PERPRISE是一项为期12个月的,多中心的,前性的,在德国进行的观察性研究.
- 100名年龄≥18岁的FBTCS或GTCS患者接受了perampanel作为补充或替代疗法.
- 临时终点包括保留率,频率变化和6个月后治疗出现的不良事件 (TEAE).
主要成果:
- 六个月的保留率为78.0% (83.7%的添加,72.7%的替代).
- 58.8%的患者实现了无发作,在6个月后的响应率为82.6%,50%.
- 在48.0%的患者中发生了TEAE (头,疲劳,烦躁最常见);16.0%因TEAE而退出.
结论:
- 在现实环境中,Perampanel在现实环境中表现出有利的保留和控制.
- 当perampanel被用作早期线治疗时,疗效更大.
- 来自PERPRISE的临时数据为GTCS和FBTCS患者的佩拉曼内尔使用提供了宝贵的见解.
更多相关视频
06:58Non-restraining EEG Radiotelemetry: Epidural and Deep Intracerebral Stereotaxic EEG Electrode Placement
Published on: June 25, 2016
10:22Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
Published on: December 6, 2016
相关概念视频
Antiepileptic Drugs: Glutamate Antagonists
Antiepileptic Drugs: GABAergic Pathway Potentiators
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
Antiepileptic Drugs: Sodium Channel Blockers
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
Electroconvulsive Therapy
