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内皮细胞特异性的mTOR减少改善了与年龄相关的动脉和代谢功能障碍

Md Torikul Islam¹, Shelby A Hall¹, Tavia Dutson²

¹Department of Nutrition and Integrative Physiology, The University of Utah, Salt Lake City, Utah, USA.

|November 29, 2023

概括

在老老鼠的内皮中减少哺乳动物目标拉巴胺素 (mTOR) 逆转了动脉硬化和改善了代谢功能. 这种有针对性的方法为未来的抗衰老药物开发提供了潜力.

科学领域:

生物遗传学生物遗传学
血管生物学血管生物学
代谢性疾病代谢性疾病

背景情况:

系统性抑制哺乳动物目标拉巴胺素 (mTOR) 显示出抗衰老作用,延迟与年龄相关的动脉和代谢功能障碍.
介导这些益处的机制和特定组织尚未完全理解.
内皮S6K激活,一个下游mTOR目标,在动脉中随着年龄的增长而增加.

研究的目的:

为了研究拉巴胺 (mTOR) 的内皮哺乳动物点在与年龄相关的动脉和代谢功能障碍中的作用.
为了确定是否有针对性的减少内皮mTOR可以改善老化表型在小鼠.

主要方法:

在小鼠中诱导了mTOR的内皮细胞特异性缺失.
评估动脉功能,包括动脉硬化和内皮依赖扩张 (EDD).
评估了代谢参数,如葡萄糖耐受性,肝脏葡萄糖生成和脂质耐受性.
测量了动脉和其他组织中的细胞衰老,炎症和氧化应激标志物.

主要成果:

在老小鼠中,内皮特异性mTOR降低逆转了与年龄相关的动脉硬化,并改善了EDD.
这种干预减少了动脉细胞衰老,炎症和氧化应激.
在老老鼠中改善了葡萄糖和脂质耐受性,与减弱的肝脏葡萄糖生成有关.
在肺,肝脏和脂肪组织中抑制衰老和炎症基因表达.

结论:

在老年时有针对性的降低乳腺内皮乳腺目标拉巴胺素 (mTOR) 改善了动脉和代谢功能.
内皮mTOR在调解与年龄相关的血管和代谢衰退方面发挥着关键作用.
研究结果表明,内皮mTOR是与年龄有关的疾病的潜在治疗点.

关键词:

衰老的衰老衰老的衰老动脉硬性动脉硬性内皮细胞是内皮细胞.这是一种炎症炎症炎症炎症.代谢功能的代谢功能氧化应激是一种氧化应激.衰老是一种老化.血管扩张血管扩张

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