在晚期肝细胞癌中免疫治疗的并发症
Young-Gi Song1, Jeong-Ju Yoo1, Sang Gyune Kim1
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Soonchunhyang University Hospital Bucheon, Soonchunhyang University College of Medicine, Bucheon, Korea.
免疫检查点抑制剂 (ICI) 提供癌症治疗益处,但可能导致不可预测的免疫相关不良事件 (irAEs). 本综述详细介绍了常见的IRE,它们的管理,以及在开始ICI治疗之前需要对患者进行全面评估的需要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 免疫检查点抑制剂 (ICI) 是一种重要的癌症治疗药物.
- 与免疫相关的不良事件 (irAEs) 是常见的,不可预测的,并且可能是持久的.
- 在患者护理中,平衡ICI益处与irAE风险至关重要.
研究的目的:
- 审查与免疫检查点抑制剂 (ICI) 相关的常见免疫相关不良事件 (irAEs).
- 探索与不同ICI代理相关的特定IRE.
- 总结irAE管理策略,并突出罕见,严重的事件.
主要方法:
- 系统审查大量引用的原始文章和关于ICI相关不良事件的评论.
- 分析报告的IRE,包括常见和罕见的表现.
- 识别经常受到irAEs影响的器官系统.
主要成果:
- 常见的irAEs包括疲劳,发烧,皮疹,,腹,食欲下降,恶心,腹痛,便秘,肝炎和甲状腺功能低下.
- 治疗前的评估应包括胃肠道,心脏,神经,内分泌 (特别是甲状腺) 和眼科系统.
- 在不同的ICI代理人中,特定的irAE配置文件有所不同.
结论:
- 接受ICI治疗的患者必须进行全面的治疗前评估.
- 了解常见和罕见的irAEs对于及时诊断和管理至关重要.
- 有效的管理策略可用于各种irAEs,改善患者的治疗结果.
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