血酸和胃肠道对三种不同形式的酸封装的反应
D J Tinnion1, F M Marticorena2, B Dobson1
1Department of Sport and Physical Activity, Edge Hill, Ormskirk, UK.
Research in sports medicine (Print)
|November 29, 2023
概括
肠道涂层或延迟释放囊并没有显著减少酸的胃肠道症状. 然而,摄入形式影响了血液中的二碳酸盐水平,这表明对酸平衡的影响各不相同.
科学领域:
- 运动生理学 运动生理学
- 营养生物化学 营养生物化学
- 胃肠病学 胃肠病学
背景情况:
- 酸盐 (SC) 补充剂用于在运动期间缓冲酸.
- 肠道涂层 (ENT) 或延迟释放 (DEL) 囊可以减轻与SC摄入相关的胃肠道症状 (GIS).
- 不同的SC囊配方对血液酸平衡的影响尚不清楚.
研究的目的:
- 调查不同酸 (SC) 囊配方 (凝,延迟释放,肠道涂层) 对胃肠道症状 (GIS) 的影响.
- 为了确定这些配方在急性SC摄入后对血液酸平衡的影响.
- 评估SC补充剂个人化摄入策略的必要性.
主要方法:
- 14名活跃的男性通过凝 (GEL),延迟释放 (DEL) 或肠道涂层 (ENT) 囊摄入了减少剂量的酸 (0.4 g.kg-1 BM).
- 还进行了化控制 (CON) (0.07 g.kg-1 BM).
- 摄入后4小时内监测血液酸平衡和GIS.
主要成果:
- 摄入形式对经历的胃肠道症状总量没有显著影响.
- 血液二碳酸盐 ([HCO3-) 的水平与凝 (GEL) 囊相比,与肠外涂层 (ENT) 囊相比显著更高.
- 食SC的急性摄入,无论形式如何,显著增加了血液二碳酸盐的休息水平,并观察到持续的升高.
结论:
- 酸囊的配方不会显著改变胃肠道症状,但可以影响血液二碳酸盐水平.
- 降低剂量的SC引起最小的GIS,并导致血液二碳酸盐的显著,持续增加,无论囊类型.
- 这些发现挑战了高度个性化的摄入策略的必要性,突出了SC诱导的性病的持续的人体营养潜力.
相关概念视频
01:31Acid Suppressive Drugs for Peptic Ulcer Disease: Antacids
374
In the complex environment of the gastric lumen, excessive acid secretion can lead to the formation or worsening of ulcers within the delicate mucosal layer. Antacids, such as sodium bicarbonate and calcium carbonate, provide relief by neutralizing this acid, transforming it into harmless salt and water. This neutralization process raises the gastric pH from a highly acidic level of 1 to a more basic 3-4, reducing the acidity within the stomach.
However, this neutralization reaction between...
However, this neutralization reaction between...
374
01:18Titration of Polyprotic Base with a Strong Acid
803
The titration of a polyprotic base such as sodium carbonate with a strong acid such as hydrochloric acid results in two equivalence points on the titration curve. At the first equivalence point, the carbonate ions in the base are completely converted to bicarbonate ions. The second equivalence point corresponds to the complete conversion of bicarbonate ions to carbonic acid, which dissociates into carbon dioxide and water. The region before the first equivalence point corresponds to the...
803
03:26Acids, Bases and Neutralization Reactions
54.8K
An acid-base reaction is one in which a hydrogen ion, H+, is transferred from one chemical species to another. Such reactions are of central importance to numerous natural and technological processes, ranging from the chemical transformations within cells or lakes and oceans to the industrial-scale production of fertilizers, pharmaceuticals, and other substances essential to the society.
54.8K
01:25Acid-Base Balance
412
The human body maintains a narrow pH range regulated through acid-base balance. This balance is crucial as changes in the hydrogen ion concentration can disrupt cell membrane stability, alter protein structures, and change enzyme activities. The normal pH of arterial blood is 7.4, venous blood and interstitial fluid is 7.35, and intracellular fluid averages 7.0.
When the pH of arterial blood rises above 7.45, it results in a condition called alkalosis. Conversely, a drop below 7.35 leads to...
When the pH of arterial blood rises above 7.45, it results in a condition called alkalosis. Conversely, a drop below 7.35 leads to...
412
01:29Renal Regulation of Acid-Base Balance
468
Metabolic reactions in the body produce nonvolatile acids, such as sulfuric acid, which generate an acid load of approximately 1 mEq of H+ per kilogram of body weight daily. Excreting H+ in the urine is essential to balance this acid load.
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
468
01:14Prevention of Further Absorption of Poison
829
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
829