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尺寸和剂量取决于全身器官对酸纳米材料的转录性反应

Yu Li^1,2,3,4, Wei Jiang^3,4, Nanfang Nie^1,3,4

¹Clinical Research Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P. R. China.

ACS applied materials & interfaces

|November 29, 2023

概括

这项研究揭示了纳米粒子大小和剂量如何影响全身器官反应. 酸纳米材料表现出剂量依赖的影响,较小的无形酸 (ACP) 纳米颗粒会在器官中造成更大的风险.

科学领域:

生物医学工程生物医学工程
毒理学毒理学毒理学
纳米技术纳米技术

背景情况:

纳米材料提供临床益处,但由于潜在的全身透,存在风险.
对纳米粒子透的可靠全身风险评估仍未得到充分研究.

研究的目的:

为了研究在体内给予酸纳米材料后,多个器官中的尺寸和剂量依赖的转录基因反应.
建立基于转录基因数据的纳米材料风险预测模型.

主要方法:

无形酸盐 (ACP,~1 nm) 和ACP-M (~10 nm) 纳米材料在不同的剂量中给小鼠模型.
多器官转录学分析心脏,肝脏,脏,肺,脏和大脑组织.
使用转录基因响应数据开发风险预测模型.

主要成果:

基因表达轨迹与纳米材料剂量相关,并显示了组织特异性风险效应.
肺组织表现出显著的风险标志 (亡,增殖,细胞应激);脏显示出免疫反应和DNA损伤标志.
与较大的器官相比,较小的ACP纳米粒子在多个器官中诱导了更明显的组织特异性风险效应.

结论:

结果提供了一个尺寸和剂量依赖的纳米颗粒在转录层面的风险评估尺度.
开发的风险预测模型可以帮助评估与本地纳米材料交付相关的风险.
这项研究有助于建立稳健的临床应用中纳米材料的风险评估策略.

关键词:

酸纳米集团是酸的纳米集团.矿物化的矿化.纳米材料是一种纳米材料.风险预测风险预测转录组学转录组学是指转录组学.

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