人类非同义单核酸多态性ACE2基因可能影响SARS-CoV-2欧米克朗亚型的传染性
Arijit Samanta1, Ashif Ahamed2, Syed Sahajada Mahafujul Alam1
1Applied Biochemistry Laboratory, Department of Biological Sciences, Aliah University, Kolkata 700160, India.
Current pharmaceutical design
|November 29, 2023
概括
抗胰岛素I转化酶2 (ACE2) 受体的遗传变异对SARS-CoV-2 Omicron亚变体的结合有影响. 特定的ACE2基因突变会影响病毒的进入和感染易感性.
科学领域:
- 病毒学 病毒学
- 遗传学 是一个遗传学.
- 结构生物学 结构生物学
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 是导致COVID-19的原因.
- 抗胰岛素I转化酶2 (ACE2) 受体对于SARS-CoV-2进入宿主细胞至关重要.
- 在ACE2基因中的非同义单核酸多态 (nsSNP) 可以改变它与病毒的相互作用.
研究的目的:
- 研究人类ACE2基因中有害nsSNP对其与SARS-CoV-2Omicron亚变体尖端蛋白受体结合域 (RBD) 的相互作用的影响.
- 为了识别特定的ACE2变体,这些变体表现出与Omicron RBD.的改变结合亲缘关系.
主要方法:
- 用蛋白质与蛋白质对接模拟来分析ACE2:RBD相互作用.
- 人类ACE2基因中的有害nsSNP被选择用于计算分析.
主要成果:
- 在ACE2中出现的几种误解突变 (例如,A242V,R708W,G405E) 与Omicron亚变体RBDs具有更强的结合亲和力.
- 其他nsSNP (例如,R768W,Y654S,F588S) 与Omicron亚变体RBDs的结合亲和力较低.
结论:
- 人类ACE2基因中的nsSNP可以修改ACE2蛋白质的结构和功能.
- 这些ACE2的变化可能会影响宿主对SARS-CoV-2 Omicron亚型的敏感性.
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