自然化合物作为Aβ和Tau聚合的抑制剂
Kadja Luana Chagas Monteiro1, Thiago Mendonça de Aquino1, Edeildo Ferreira da Silva-Júnior2
1Research Group on Therapeutic Strategies - GPET, Laboratory of Synthesis and Research in Medicinal Chemistry - LSPMED, Institute of Chemistry and Biotechnology, Federal University of Alagoas, Maceió, Alagoas, Brazil.
CNS & neurological disorders drug targets
|November 29, 2023
概括
天然化合物在对抗神经退行性疾病,如阿尔茨海默病 (AD) 方面表现有前途. 本综述探讨了130多项关于天然产品的研究,这些产品可以抑制粉样质斑块和团,可能减缓AD的进展.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 自然产品化学 自然产品化学
背景情况:
- 神经退行性疾病,包括阿尔茨海默病 (AD),帕金森病 (PD) 和肌缩性侧面硬化症 (ALS),涉及逐渐失去神经元.
- 目前的研究重点是确定治疗药物来缓解神经元退化,特别是在AD.
- 阿尔茨海默病的主要病理特征包括粉样质斑块和神经纤维质团的积累.
研究的目的:
- 综合审查研究的天然产品,以检查它们在抑制粉样斑块和团形成方面的潜力.
- 探索与阿尔茨海默病相关的自然化合物的多样化药理机制.
- 评估天然产品在缓解或延迟阿尔茨海默病进展方面的潜力.
主要方法:
- 系统的文献搜索和大约130项研究的综述.
- 分析着重于天然产品的研究及其对粉体生成和病的影响.
- 对研究自然化合物对AD病理特征的抑制潜力的研究的评估.
主要成果:
- 一系列天然化合物对神经退行过程表现出多方面的活性.
- 几种天然产品在抑制粉样斑块的形成方面表现出有效性.
- 许多化合物显示出防止蛋白聚合成的潜力.
结论:
- 自然产品代表了对抗阿尔茨海默病的新型治疗策略的有希望的来源.
- 抑制粉样质斑块和团的形成是基于天然产品的AD干预措施的关键目标.
- 对这些天然药物的进一步研究可能会导致神经退行性疾病的有效治疗方法.
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