在炎症性肠病中的心血管表现
Anish Meda1, Fremita Fredrick1, Urvashi Rathod2
1Avalon University School of Medicine, Willemstad, Curacao.
Current cardiology reviews
|November 29, 2023
概括
炎症性肠病 (IBD) 通过炎症和代谢变化增加心血管疾病的风险. 通过改变生活方式和药物来管理IBD可以减轻这些风险.
科学领域:
- 胃肠病学和心脏病学
- 系统性炎症 系统性炎症
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 炎症性肠病 (IBD),包括克罗恩病和性结肠炎,与影响胃肠道的全身炎症有关.
- IBD与肠外表现的风险增加有关,特别是心血管疾病 (CVD),显著影响患者的生活质量.
- 在IBD中发生的病理生理变化包括微生物组的改变,内毒性,以及失调的葡萄糖和脂质代谢,这有助于心血管疾病风险.
研究的目的:
- 检查炎症性肠病对心血管并发症风险的影响.
- 研究药物治疗在控制与IBD相关的心血管风险方面的作用.
- 综合当前关于IBD与心血管健康之间的关系的文献.
主要方法:
- 使用PubMed.com进行了全面的文献搜索.
- 关键词包括"炎症性肠病"",克罗恩病"",性结肠炎"",心血管疾病"",心周炎"和"血栓栓塞".
- 分析包括从临床试验,元分析,队列研究和发布到2023年3月的指南中获取的数据.
主要成果:
- IBD患者表现出心血管风险标志物升高,包括心动脉内膜介质厚度增加和脉冲波速度增加,以及流媒体扩张减少.
- IBD患者的高凝血状态,以血栓细胞瘤和凝血激活为特征,增加了静脉和动脉血栓事件的风险.
- IBD病理生理学涉及微生物组失调,内毒性,以及导致心血管并发症的代谢障碍.
结论:
- 炎症性肠病显著增加心血管疾病和血栓事件的风险.
- 改变生活方式 (戒烟,饮食,运动) 和适当的药物治疗对于降低IBD患者心血管疾病风险至关重要.
- 需要进一步的研究和综合管理策略来解决炎症性肠病中心血管负担.
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