在非糖尿病患者中与淋巴细胞过相关的心血管风险:增加可见性至关重要
1Diplomatura Terapias Reemplazo Renal, Universidad de Ciencias Empresariales y Sociales, Caracas 4599 C1419 EJU, Argentina.
Current hypertension reviews
|November 29, 2023
概括
淋巴细胞过 (GHF) 是一个重要的心血管风险因素,即使在非糖尿病人. 早期识别GHF,特别是在中年人群中,对于预防病和死亡率至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 淋巴细胞过 (GHF) 是病和心血管风险的已知预测因素.
- 球膜过率 (GFR) 的上限表示GHF的定义很差,这使临床实践复杂化.
- GHF的死亡风险与中期慢性病 (CKD) 的死亡风险相当,即使在非白病患者中也是如此.
研究的目的:
- 审查目前对GHF作为心血管和死亡风险因素的理解.
- 突出定义GHF切断值及其临床影响的挑战.
- 强调需要提高对GHF的认识和有针对性的干预措施.
主要方法:
- 系统性审查涉及大约360万个人的研究.
- 分析GFR值及其与死亡风险的关联.
- 对 CKD-EPI GFR 公式的性能评估.
主要成果:
- 较高的GFR值,从106.6到113.7毫升/分钟,与死亡风险增加有关.
- CKD-EPI公式在更高的GFR值和风险预测时表现出更好的准确性.
- GHF在看似健康的个体中普遍存在,这些人有肥胖和高血压等危险因素.
结论:
- 需要就GHF截止值达成共识,考虑到性别和年龄的差异.
- 专注于中年人群可能为干预和扭转GHF后果提供更大的机会.
- 医疗界的提高意识,生活方式的改变,以及潜在的治疗药物,如SGLT2抑制剂,对于管理GHF至关重要.
相关概念视频
01:20Renal Corpuscle
2.3K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
2.3K
01:28Glomerular Filtration Rate and its Regulation
2.8K
The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
2.8K
01:02Renal Drug Excretion: Glomerular Filtration
276
The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production occurs. A nephron has two main components: a renal corpuscle and a renal tubule.
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles....
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles....
276
01:17Factors Affecting Renal Clearance: Renal Impairment
99
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
99
01:22Heart Failure Drugs: Diuretics
396
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
396
01:16Antihypertensive Drugs: Action of Diuretics
786
Diuretics are antihypertensive drugs used to treat hypertension resulting from sodium and water retention. Sodium, vital for fluid balance and nerve or muscle function, is regulated by the kidneys through millions of nephrons. Blood enters nephrons via afferent arterioles, which branch into capillaries called glomeruli. These filter blood plasma, allowing water and solutes, like sodium ions, to pass through capillary walls into Bowman's capsule. The filtrate then flows through various...
786