患有先天性黑色细胞瘤的儿童的维生素D状况
Connor T Hughes1,2,3, Jusvinder Dadhra4, Satyamaanasa Polubothu1,2,3
1Paediatric Dermatology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Pediatric dermatology
|November 29, 2023
概括
患有先天性黑色细胞瘤 (CMN) 的患者往往缺乏维生素D. 冬季对患有CMN的儿童建议补充维生素D,而不需要进行常规血液检查.
科学领域:
- 儿科皮肤病学 儿科皮肤病学
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 先天性黑色细胞 (CMN) 是一种罕见的与黑色素瘤风险增加相关的出生.
- 之前对非CMN黑色素瘤队列的研究表明,维生素D水平与患者的结果之间存在潜在联系.
研究的目的:
- 在被诊断为先天性黑色细胞瘤的儿童中调查25-氧维生素D水平.
- 为了确定这种儿科队列中维生素D不足和缺乏的患病率.
主要方法:
- 分析了40名患有先天性黑色细胞瘤的儿童的血样本.
- 对25-氧维生素D度的测量.
主要成果:
- 显著比例的CMN儿童表现出维生素D不足 (27%) 和缺乏 (13%).
- 观察到的维生素D水平与通常在欧洲人群中观察到的水平相似.
结论:
- 这些发现支持在患有CMN的儿童中定期补充维生素D的建议,特别是在冬季.
- 对于所有CMN患者来说,常规血清维生素D测量不被认为是必要的,与现有的英国指南保持一致.
相关概念视频
Skin Cancer
4.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.2K
Changes in Skin Color: Clinical Perspectives
2.0K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
2.0K
Connective Tissue Cell Types
3.2K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
3.2K
Pigmentation
2.4K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
2.4K


