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使用PAsp-Sr复合体的多电解质-离子复合体诱导具有抗菌能力的生物模拟矿化.

Yuedan Xu1, Dongni Shen1, Zihuai Zhou1

  • 1Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, 310000, China.

Advanced healthcare materials
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概括

这项研究引入了一种新的生物仿真矿化技术,使用和来重新矿化牙. 这种新方法可以恢复牙.

关键词:
这是一种抗菌药物,具有抗菌作用.牙腐烂是指牙的腐烂.纤维细胞内矿化聚电解质-复合物是预先体的过程前体.是的组成部分.

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科学领域:

  • 生物材料科学 生物材料科学
  • 牙科材料 牙科材料
  • 纳米技术纳米技术

背景情况:

  • 再矿化牙具有抗菌性质仍然是一个重要的牙科挑战.
  • 之前的多电解质-复合物前体 (PCCP) 过程使得原蛋白迅速矿化.

研究的目的:

  • 通过用来代替来增强牙重矿化来探索一个扩展的PCCP概念.
  • 开发一种抗菌和生物相容的牙重矿化方法.

主要方法:

  • 使用了多酸- (PAsp-Sr) 悬浮液,然后用酸溶液进行生物仿真矿化.
  • 采用了包括TEM,3D STORM,EDX,FTIR和HRTEM-SAED在内的技术进行表征.
  • 在体外和体内进行了针对Streptococcus mutans的抗菌分析.
  • 进行了细胞毒性和口腔粘膜刺激测试.

主要成果:

  • 通过使用 Sr&F-编的酸 (HAp) 成功实现了对原纤维和非矿化牙的生物仿真矿化.
  • 在体外和体内表现出显著的抗菌活性,用于对抗 Streptococcus mutans.
  • 将非矿物化牙的机械性能 (弹性模量,微硬度) 恢复到几乎完好无损的水平.
  • 证实了矿化介质的优良生物相容性.

结论:

  • 扩展的PCCP概念,使用和,提供了一个有前途的方法,创造抗菌再生矿物质牙.
  • 这种生物仿真矿化技术产生具有优异生物相容性和恢复机械完整性的离子化HAp.
  • 为具有增强功能的先进牙科修复材料开辟了新的途径.