长效眼镜注射剂:我们是否在朝着正确的方向看?
Mickael Dang1,2, Molly S Shoichet1,2,3
1Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON, M5S 3E5, Canada.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|November 29, 2023
概括
基于生物材料的长效注射剂 (LAI) 为眼部药物输送挑战提供了一个有希望的解决方案. 这些先进的配方增强了药物停留时间和生物可用性,改善了眼部疾病的治疗结果.
科学领域:
- 眼科医生 眼科 眼科
- 生物材料科学 生物材料科学
- 药品制造 药品制造 药品制造
背景情况:
- 由于眼睛复杂的解剖学和生理障碍,眼部药物输送面临重大障碍.
- 快速清除和药物的生物可用性差,限制了传统眼部治疗疗法的有效性.
研究的目的:
- 审查用于眼部药物输送的有希望的长效注射剂 (LAI).
- 探索新的设计策略,以提高眼部组织的治疗结果.
主要方法:
- 对基于生物材料的LAI用于眼睛应用的当前文献的综述.
- 对持续药物释放和有针对性的药物输送的设计策略的分析.
主要成果:
- LAI 显示出持续治疗效果和延长局部药物停留时间的潜力.
- 工程 LAI 可以改善药物向性和穿越眼障碍的透.
结论:
- 基于生物材料的LAI在克服眼部药物输送限制方面取得了重大进展.
- 这些创新方法有望改善眼部疾病的治疗.
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