儿科瘤学患者的SARS-CoV-2疫苗接种反应
Amber Marie D'Souza1, Maria Thomas1, Manu Gnanamony1
1Department of Pediatrics, University of Illinois College of Medicine, Peoria, Illinois, USA.
Pediatric blood & cancer
|November 29, 2023
概括
儿科瘤学患者对严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 疫苗接种显示出低于最佳的免疫反应. 补充剂对保护至关重要,但血液细胞计数可能不能指导最佳时间.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科瘤学 儿科瘤学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 有限的数据存在于重症急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 疫苗免疫反应在儿科瘤学患者.
- 了解免疫原性对于在这种免疫受损群体的咨询和风险管理至关重要.
研究的目的:
- 在儿科瘤病患者中评估SARS-CoV-2疫苗接种的免疫性.
- 确定影响该群体疫苗反应的临床因素.
主要方法:
- 注册的儿科患者 (0-25岁) 正在接受癌症治疗.
- 接种疫苗前和接种疫苗后的多个时间点收集的血液样本.
- 在患者和健康对照中测量了中和抗体 (B细胞) 和干扰素马分泌 (T细胞).
主要成果:
- 只有36.4%可评估的儿科瘤患者表现出足够的B细胞反应.
- 一个较高的比例 (77.8%) 显示了足够的T细胞反应.
- 根据绝对淋巴细胞计数或治疗强度,没有观察到免疫力的显著差异.
结论:
- 儿科瘤学患者对SARS-CoV-2疫苗接种有低于最佳的免疫反应.
- 强剂量对于最佳的COVID-19保护至关重要.
- 血细胞计数不太可能有效地决定疫苗的时间.
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