在消除了Helicobacter pylori之后,缩性胃炎和肠道代谢会逆转吗?
Yongqiang Liang1,2,3, Yuanhai Yang2,4, Ruiheng Nong2,4
1Department of Gastroenterology, Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, Guangdong, People's Republic of China.
Helicobacter
|November 29, 2023
概括
根除Helicobacter pylori (H. pylori) 显著扭转了缩性胃炎 (AG) 和肠道代谢 (IM). 这一元分析证实,根除H. pylori可以改善这些疾病,尤其是在早期.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 在瘤学瘤学.
背景情况:
- 缩性胃炎 (AG) 和肠道代谢 (IM) 是癌前的疾病.
- Helicobacter pylori (H. pylori) 根除在逆转 AG 和 IM 的作用仍在争论中.
研究的目的:
- 进行一项元分析,评估H. pylori根除对AG和IM的影响.
- 综合现有研究的证据,以澄清H. pylori根除和这些胃病之间的关系.
主要方法:
- 在PubMed,Web of Science和EMBASE数据库中进行系统的文献搜索,截至2023年4月.
- 包括流行病学研究报告的得分或几率比率 (ORs) 的AG和IM在H. pylori根除之前和之后.
- 使用加权平均差异 (WMD) 和 95% 置信区间 (CI) 的聚合 ORs进行分析.
主要成果:
- 包括20项研究,5242名参与者.
- 根除H. pylori显著降低了腺缩 (GA) 和IM分数,无论是在 antrum 和 corpus.
- 在根除后显著改善AG (合并OR2.96) 和IM (合并OR2.41).
- 结果在各个子组分析中是一致的,并且对出版偏差调整有很强的依据.
结论:
- 根除 H. pylori 是改善缩性胃炎的有效策略.
- 根除H. pylori可以显著逆转肠道代谢.
- 用H. pylori根除的早期干预表明胃健康有希望的结果.
相关概念视频
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