来自Ribes nigrum的富含安东素的提取物抑制了脂肪细胞中甘油三和胆固醇的积累
Laura Montaldo1, Alicia Gallo2, Gabriela Rocha1,3
1Universidad Nacional de Luján, Departamento de Ciencias Básicas, Av Constitución y Ruta 5, Luján, Buenos Aires, 6700, Argentina.
Therapeutic delivery
|November 29, 2023
概括
卡西斯提取物含有丰富的抗生素,显示出强大的抗氧化和抗原性质. 这种天然化合物有效地减少了成熟脂肪细胞中的脂质积累,为肥胖提供了潜在的治疗途径.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 营养保健品 营养保健品
背景情况:
- 肥胖是一个重大的全球健康挑战,需要新的治疗策略.
- 成熟的脂肪细胞作为研究脂质代谢和肥胖症的关键模型.
- 自然化合物越来越多地因其生物活性特性而受到研究.
研究的目的:
- 为了评估酶性 (Ribes nigrum) 提取物的抗氧化能力.
- 评估卡西斯提取物对成熟的3T3-L1脂肪细胞的抗基效应.
- 确定安东含量在观察到的生物活性中的作用.
主要方法:
- 生物活性化合物的酶性提取从Ribes nigrum使用细胞酶和pectinase.
- 提取物的抗氧化剂产量和抗氧化剂能力的量化.
- 在体外测试中,使用3T3-L1脂肪细胞处理了囊提取物.
主要成果:
- 酵素提取物产生了高度的安托西亚尼.
- 卡西斯提取物表现出显著的抗氧化活性.
- 用提取物治疗可使脂肪细胞中的细胞内甘油三水平降低62%,胆固醇降低32%.
结论:
- 酶性卡西斯提取物的高抗氧化活性归因于其丰富的安托西亚宁含量.
- 卡西斯提取物有效地抑制成熟脂肪细胞中的脂质积累.
- 这项研究强调了Ribes nigrum提取物作为功能性食品成分或治疗肥胖的治疗剂的潜力.
关键词:
在3T3-L1细胞中.脂肪细胞 (adipocytes) 是一种脂肪细胞.安托西安尼尼 (anthocyanin) 是一种卡西斯酶提取物 卡西斯酶提取物细胞培养培养的细胞培养.纤维素酶是一种纤维素酶.胆固醇 胆固醇 胆固醇 是一种肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖这种药物是pectinase.甘油三胺的使用方法更多相关视频
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