温度对早产和满产新生儿生物流体中普雷塞普辛分析前稳定性的影响
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Ebe D'Adamo1, Valentina Botondi1, Luigi Falconio2
1Neonatal Intensive Care Unit, G. d'Annunzio University, Chieti, Italy.
Clinical chemistry and laboratory medicine
|November 29, 2023
概括
新生儿败血症的生物标志物前素在解后在血液,尿液和唾液中保持稳定. 这种稳定性支持其用于诊断和监测婴儿周围性败血症.
科学领域:
- 新生儿医学 新生儿医学
- 生物标志物研究 生物标志物研究
- 临床诊断 临床诊断 临床诊断
背景情况:
- 热稳定性对于可靠的临床和研究分析物至关重要.
- 前素是新生儿早期败血症诊断的一个有前途的生物标志物.
- 在各种存储条件下,关于前素稳定性的数据有限.
研究的目的:
- 为了研究婴儿血液,尿液和唾液样本中普西的热稳定性.
- 在解后的四个时间点评估前素的稳定性.
主要方法:
- 在24名早产和晚产婴儿进行了一项观察性研究.
- 生物样本 (血液,尿液,唾液) 在-80°C下保存了18个月.
- 在解 (T0) 和解后24,48,72小时 (T1,T2,T3) 测量了前素水平.
主要成果:
- 在任何生物流体中,在四个时间点 (T0-T3) 中没有观察到前素水平的显著差异.
- 在血液和唾液样本中,先素水平没有显著差异.
- 尿液样本显示,与血液和唾液相比,所有时间点的普雷塞普辛水平显著更高.
结论:
- 在长期冷藏后,普雷塞普辛在血液,尿液和唾液中表现出优异的分析前热稳定性.
- 这些发现支持了前素作为诊断和监测围产性败血症的生物标志物的可靠性.
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