对囊性纤维化患者长期药物坚持的评估:综合方法
Thomas Platt1, Lauren N Kormelink1,2, Elizabeth B Autry1
1Department of Pharmacy Practice and Science, University of Kentucky Healthcare, University of Kentucky College of Pharmacy, Lexington, Kentucky, USA.
Pediatric pulmonology
|November 29, 2023
概括
综合特种药房服务改善了囊性纤维化 (CF) 患者的多尔纳斯α合. 与非TCP服务相比,全方位护理药房 (TCP) 显示了更高的药物坚持,特别是在成人患者中.
科学领域:
- 药物经济学 药物经济学
- 健康 结果 研究 研究 结果
- 专业药房实践 专业药房实践
背景情况:
- 囊性纤维化 (CF) 是一种遗传性疾病,需要复杂的治疗.
- 2014年,药物获取障碍影响了43%的CF患者.
- 2016年实施了一家集成的专业药房,提供全方位护理药房 (TCP) 服务,以提高遵守率.
研究的目的:
- 评估综合特种药房的全方位护理药房 (TCP) 服务对囊性纤维化 (CF) 患者药物坚持的影响.
- 评估TCP模型是否对药物坚持率产生积极影响.
主要方法:
- 在治疗的前三年中,使用覆盖日数比例 (PDC) 测量了药物坚持.
- 对于每年至少填充三次的药物,PDC是计算出来的.
- 患有PDC<80%的患者被归类为不坚持的患者,并接受了基于原因的图表审查.
主要成果:
- 与非TCP组 (66.0%; p=.006) 相比,TCP队列中的患者在第一年 (81.3% PDC) 显示出对多尔纳斯α的坚持明显更高.
- 这种依从性改善在TCP组内的成年患者中更为明显.
- 对于其他药物或患者群体来说,没有观察到统计学上显著的坚持差异.
结论:
- 在学术医疗中心内整合特种药房服务,如TCP,改善了dornase alfa的坚持.
- 需要进一步的研究来比较TCP服务与外部药房模型,以充分理解TCP的影响.
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