尿酸可以影响膀癌中的免疫微环境吗? 一个单中心的多omics研究研究
Haotian Chen1,2, Donghui Shi3, Changfeng Guo4
1Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Molecular carcinogenesis
|November 29, 2023
概括
高尿酸 (UA) 水平与更糟糕的膀癌 (BCa) 预后和免疫疗法的有效性降低有关. 这项研究确定UA是影响BCa进展和患者生存的关键因素.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 癌症研究 癌症研究
- 免疫学 免疫学 免疫学
背景情况:
- 代谢异常影响膀癌 (BCa) 的进展和瘤微环境.
- 尿酸 (UA) 的作用是纯素代谢产物,在BCa代谢和免疫疗法反应中并不清楚.
研究的目的:
- 调查尿酸 (UA) 在膀癌 (BCa) 的预后价值.
- 探索UA和BCa患者免疫治疗反应之间的关联.
主要方法:
- 对39名PD-1治疗患者和169名彻底囊切除BCa患者的回顾性分析.
- 建立一个超尿血症小鼠模型与BCa异种移植.
- 多原子分析包括单细胞测序和UA相关基因特征的构建.
主要成果:
- 高UA水平与更差的预后相关,并且是BCa患者癌症特异性生存的独立风险因素 (p=0.007).
- 超尿血症小鼠表现出瘤体重和体积增加,CD8+和CD4+T细胞显著下降.
- 与UA相关的基因在免疫治疗不响应者的CD8+T细胞中升高,与UA相关的特征预测了生存率.
结论:
- 尿酸 (UA) 作为膀癌 (BCa) 的独立预后生物标志物.
- 升高的UA水平与BCa.的较差结果和免疫治疗反应减弱有关.
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