神经SARS-CoV-2感染和炎症反射功能障碍:是否存在因果关系?
Ulf Andersson1, Kevin J Tracey2
1Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Journal of internal medicine
|November 29, 2023
概括
感染SARS-CoV-2可能会损害迷走神经的炎症反射,导致细胞因子风暴和超级炎症. 这种功能障碍可以解释严重的COVID-19症状,并表明潜在的治疗点.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 自主功能障碍在SARS-CoV-2感染中很常见,但机制尚不清楚.
- 迷走神经的炎症反射通常会抑制细胞因子风暴.
- 这种反射的损伤可能会加剧过度炎症.
研究的目的:
- 为了调查COVID-19中的迷走神经炎症是否会损害炎症反射.
- 探索迷走神经功能障碍和COVID-19中细胞因子风暴之间的联系.
- 讨论针对炎症反射的潜在治疗干预措施.
主要方法:
- 从COVID-19受害者的病理证据的审查.
- 讨论迷走神经炎症反射的已知的机制.
- 在COVID-19中分析迷走神经炎症的潜在后果.
主要成果:
- 病理学研究结果显示,COVID-19患者的迷走神经和脑髓中存在病毒感染和炎症.
- 流动神经的炎症可能会破坏炎症反射,导致细胞因子的过度产生.
- 这种干扰与严重的COVID-19特征的高炎症和组织损伤有关.
结论:
- 在COVID-19中神经炎症是炎症反射功能障碍的合理机制.
- 炎症反射功能受损可能导致细胞因子风暴和严重的COVID-19病原体.
- 准迷走神经炎症反射可能为COVID-19提供治疗机会.
相关概念视频
Gross Anatomy of the Lungs
1.9K
The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
1.9K
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
320
Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
320
Gastritis-II: Pathophysiology
344
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
344
Somatic Spinal Reflexes
2.1K
Somatic spinal reflexes are rapid, involuntary muscular responses to external stimuli that involve the somatic musculature and the spinal cord.
One of the most well-known somatic spinal reflexes is the stretch reflex, which is activated by the sudden stretching of a muscle. This reflex involves the activation of specialized sensory receptors called muscle spindles, which are located in the muscle tissue and detect changes in the length and speed of muscle contractions. When a muscle is suddenly...
One of the most well-known somatic spinal reflexes is the stretch reflex, which is activated by the sudden stretching of a muscle. This reflex involves the activation of specialized sensory receptors called muscle spindles, which are located in the muscle tissue and detect changes in the length and speed of muscle contractions. When a muscle is suddenly...
2.1K
Pathophysiology of Vomiting
486
Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
486
Neural Regulation
39.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.5K


