更新了无脊椎动物和藻类的慢性铜生物可用性模型.
Charlotte Nys1, Patrick Van Sprang1, Stephen Lofts2
1ARCHE Consulting, Ghent, Belgium.
Environmental toxicology and chemistry
|November 29, 2023
概括
无脊椎动物和藻类的更新的慢性铜 (Cu) 生物可用性模型是使用最近的数据和通用生物可用性模型 (gBAM) 开发的. 这些强大的模型改善了风险评估,并指导了监管应用中的安全使用.
科学领域:
- 环境化学环境化学
- 生态毒理学 生态毒理学
- 风险评估 风险评估
背景情况:
- 现有的慢性铜 (Cu) 生物可用性模型已有近二十年的历史,需要对当前欧洲风险评估进行更新.
- 最近生态毒性数据和物种化建模 (WHAM VII) 的进展为模型改进提供了机会.
研究的目的:
- 为无脊椎动物和藻类提供更新的慢性Cu生物可用性模型.
- 将最近的生态毒性数据纳入并利用WHAM VII物种化模型在一个优化的通用生物可用性模型 (gBAM) 结构中.
主要方法:
- 使用通用生物利用模型 (gBAM) 开发了无脊椎动物和藻类的更新慢性Cu生物利用模型.
- 采用了最近的生态毒性数据集和温德米尔水水性模型 (WHAM) VII.
- 模拟了pH对Cu2+毒性的影响,使用与重新校准的pH斜率 (SpH) 参数的日志线性关系.
主要成果:
- 更新的gBAM模型预测了八种物种的80%至100%的观察效应水平,其系数为2.
- 再校准的SpH参数为 -0.208无脊椎动物和 -0.975藻类.
- 模型的性能与现有的监管模型相似或更好,但在Hyalella azteca的高pH下慢性死亡率方面有一个明显的例外.
结论:
- 更新的慢性Cu生物可用性模型集是强大的,准确的,适合监管应用.
- 这些模型与鱼类生物可用性模型一起,构成了环境风险评估的完整和一致的套件.
- 更新的模型目前在欧盟化学品注册,评估,授权和限制 (REACH) 框架下使用,以确保安全使用铜.
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