具有鼻息肉的慢性鼻炎:在疾病发病过程中,乙酸细胞与B淋巴细胞对比
Harsha H Kariyawasam1,2, Louisa K James3
1Specialist Allergy and Clinical Immunology, Royal National ENT and Eastman Hospital, London.
Current opinion in allergy and clinical immunology
|November 29, 2023
概括
乙素可能不是带有鼻息肉的慢性鼻炎 (CRSwNP) 的主要驱动因素. 新出现的证据表明B细胞发挥着重要作用,为CRSwNP提供了潜在的新治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 带鼻息肉的慢性鼻炎 (CRSwNP) 是一种复杂的炎症状况.
- 在驱动CRSwNP病变发生过程中,埃索诺菲尔的作用越来越受到质疑.
- B细胞正在成为CRSwNP.的潜在关键参与者.
结论:
- 目前的证据质疑了在CRSwNP中氨基酸蛋白的中心作用.
- B细胞功能障碍可能解释了CRSwNP免疫病理学的许多方面.
- 向B细胞代表了对CRSwNP的有希望的未来治疗策略.
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