关于卡里普拉辛治疗参考范围的建议-A 简短沟通
Fabian Sattaf1, Maike Scherf-Clavel2, Stefan Unterecker2
1Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital, Frankfurt am Main.
Therapeutic drug monitoring
|November 29, 2023
概括
精神病患者的真实世界卡里普拉血清度表明当前的治疗参考范围可能过高. 这项研究支持较低的5-15 ng/mL范围,表明最佳药物监测的潜在调整.
科学领域:
- 药理学 药理学是指药理学的学科.
- 精神病学是一个精神病学.
- 临床化学 临床化学
背景情况:
- 治疗药物监测依赖于有效药物治疗的既定参考范围.
- 目前对cariprazine的治疗参考范围是估计的,缺乏现实世界的验证.
- 许多患者的卡里普拉辛血清度在现有的治疗范围之外.
研究的目的:
- 评估当前卡里普拉辛治疗参考范围的有效性.
- 在接受治疗的患者中分析 cariprazine 的真实血清度.
- 提供数据,以建立基于证据的治疗范围,为cariprazine.
主要方法:
- 对19名精神病患者血清卡里普拉辛度的回顾性分析.
- 纳入标准:没有药理动力学异常,最新可用的测量,达到稳定的剂量.
- 测量度与2017年指南 (10-20 ng/mL) 和较低的建议范围 (5-15 ng/mL) 的比较.
主要成果:
- 平均卡里普拉辛血清度为9.1 ± 4.1 ng/mL.
- 47.4%的度在10-20 ng/mL范围内.
- 78.9%的度在5-15 ng/mL范围内.
结论:
- 研究结果支持推将卡里普拉辛治疗参考范围降至5-15 ng/mL.
- 基于这些数据计算的治疗参考范围为5.0-13.2 ng/mL.
- 最佳范围可能更低,考虑到临床剂量定位实践.
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