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停止激素治疗和骨矿物质密度:体育活动是否会改变这种关系?
Alyssa N Sheedy1, Jean Wactawski-Wende2, Kathleen M Hovey2
1From the Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY.
Menopause (New York, N.Y.)
|November 29, 2023
概括
继续进行激素治疗的绝经后妇女保持了骨密度. 停止激素治疗或从不使用激素治疗导致骨质损失,身体活动没有显著影响.
科学领域:
- 老年学是指老年学的学科.
- 内分泌学 在内分泌学.
- 骨健康 骨健康 骨健康
背景情况:
- 众所周知,激素治疗 (HT) 在绝经后妇女中积极影响骨矿物质密度 (BMD).
- 2002年妇女健康倡议 (WHI) 试验结果显著改变了HT的处方模式.
- 在停止HT治疗后了解BMD变化对于管理老年妇女骨质疏松风险至关重要.
研究的目的:
- 为了检查停用HT后的绝经后妇女的BMD变化,2002年后的WHI发现.
- 调查这些女性的常规体育活动水平是否改变了BMD变化.
主要方法:
- 这是一项前性观察性研究,涉及961名绝经后妇女,来自Buffalo OsteoPerio研究.
- 在基线和5年随访期间收集的关于关节骨质量,HT使用 (非/非,当前/非,当前/当前) 和身体活动的数据.
- 根据HT状态和停止治疗,分析5年内骨质量变化.
主要成果:
- 持续治疗HT的女性在5年内没有显著的骨损失.
- 停用HT的女性经历了最大的部BMD损失 (-0.021gm/cm2).
- 从来没有使用过HT的人也显示出一些BMD损失 (-0.012 gm/cm2);身体活动没有改变这些结果.
结论:
- 在更年长的绝经后妇女中,HT的延续可以保持BMD.
- 停用HT与显著的骨质损失有关,在WHI试验后突出显示风险.
- 对骨健康的有针对性的体育活动干预措施的进一步研究是有必要的.
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