功能性下丘脑缺血:肠道微生物群的组成和外源性雌激素的作用
Giovanna Notaristefano1,2, Francesca Romana Ponziani2,3, Monia Ranalli4
1Department of Women's and Children's Health Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
功能性下丘脑缺血 (FHA) 涉及肠道疾病. 激素替代疗法 (HRT) 改善了肠道微生物群,并减少了FHA患者的炎症.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 微生物组研究 微生物组研究
- 肠-大脑轴研究研究
背景情况:
- 功能性下丘脑缺血 (FHA) 的特点是雌激素缺乏,影响多个健康系统.
- 雌激素会影响肠道微生物群,这表明FHA,环境因素和肠道微环境之间存在联系.
- 肠-大脑轴在FHA中发挥作用,突出了研究肠道微生物群变化的必要性.
研究的目的:
- 为了研究患有FHA的女性的肠道微生物群组成.
- 评估激素替代疗法 (HRT) 对FHA肠道微生物群的影响.
- 探索肠道微生物群变化,荷尔蒙状况和全身炎症之间的关系.
主要方法:
- 一项前性观察性研究,将33名FHA患者 (18-34岁) 与10名健康对照人进行比较.
- 在FHA患者中,16S rRNA基因扩增序列测定在基线和6个月后的肠道微生物群的概况.
- 临床,荷尔蒙,代谢和炎症标志物的评估.
主要成果:
- 在FHA患者和基线对照者之间肠道微生物群α多样性的显著差异.
- 在HRT后,FHA患者的Fusobacteria,Ruminococcus和Eubacterium的相对丰度增加.
- 这些微生物的转变与循环促炎细胞因子的减少有关.
结论:
- FHA与肠道失调有关,涉及肠-大脑轴.
- 在FHA患者中,HRT促进了肠道微生物群组成的有利转变.
- HRT诱导的微生物群变化与减少的全身炎症有关,验证了FHA作为一个多方面的疾病.
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